THE COMBINATION OF CURAXIN CBL0137 AND HISTONE DEACETYLASE INHIBITOR PANOBINOSTAT DELAYS KMT2A-REARRANGED LEUKEMIA PROGRESSION

The Combination of Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Delays KMT2A-Rearranged Leukemia Progression

Rearrangements of the Mixed Lineage Leukemia (MLL/KMT2A) gene Tinned Soups are present in approximately 10% of acute leukemias and characteristically define disease with poor outcome.Driven by the unmet need to develop better therapies for KMT2A-rearranged leukemia, we previously discovered that the novel anti-cancer agent, curaxin CBL0137, induces

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